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Announcements
Special Notice: May Bank Holidays
NEB UK will be closed on 6th May 2013 – orders received by 5pm on 02/05 will be delivered on 03/05. Orders received after 5pm will be delivered on 08/05.
NEB UK will be closed on 27th May 2013 – orders received by 5pm on 23/05 will be delivered on 24/05. Orders received after 5pm will be delivered on 29/05.
Announcing CutSmart Buffer: simplifying the use of NEB Restriction Enzymes.
NEB is continuously looking for ways to enhance convenience and performance for our customers. Our CutSmart Buffer incorporates BSA to enable even more enzymes to cut in a single buffer (>200 enzymes). This allows for enhanced ease of use especially when doing double digests. In addition, it eliminates the extra tube of BSA and means one less thing to think about when setting up restriction enzyme digests. CutSmart Buffer also works well with many of NEB's downstream cloning enzymes.
NEB is continuously looking for ways to enhance convenience and performance for our customers. Our CutSmart Buffer incorporates BSA to enable even more enzymes to cut in a single buffer (>200 enzymes). This allows for enhanced ease of use especially when doing double digests. In addition, it eliminates the extra tube of BSA and means one less thing to think about when setting up restriction enzyme digests. CutSmart Buffer also works well with many of NEB's downstream cloning enzymes.
What has changed?
• Over 200 of our Restriction Enzymes are switching to new CutSmart Buffer (replacing NEBuffer 4)
• CutSmart Buffer incorporates BSA to enable even more enzymes to cut in a single buffer (>200 enzymes)
• Enzymes not supplied with CutSmart Buffer will also be switching to new NEBuffers (see table)
• BSA has been added directly to the new buffers and DTT has been removed. Other buffer components remain the same*
• Over 200 of our Restriction Enzymes are switching to new CutSmart Buffer (replacing NEBuffer 4)
• CutSmart Buffer incorporates BSA to enable even more enzymes to cut in a single buffer (>200 enzymes)
• Enzymes not supplied with CutSmart Buffer will also be switching to new NEBuffers (see table)
• BSA has been added directly to the new buffers and DTT has been removed. Other buffer components remain the same*
| Old Buffer | Equivalent New Buffer | Label Colour |
| NEBuffer 1 | NEBuffer 1.1 | Yellow |
| NEBuffer 2 | NEBuffer 2.1 | Blue |
| NEBuffer 3 | NEBuffer 3.1 | Red |
| NEBuffer 4 | CutSmart Buffer | Green |
You will start to receive some of your restriction enzymes with CutSmart Buffer from 20th March 2013 and you can continue to use your current stocks of NEB restriction enzymes and buffers in conjunction with these newer ones.
Double Digests using a mixture of enzymes supplied with original NEBuffer and CutSmart Buffer.
Our Restriction Enzymes are color coded on the label for the appropriate NEBuffer and can either be used with the previously supplied NEBuffer or with the newly recommended buffer. Although using old NEBuffer is fine, we recommend using the new tube of buffer for added convenience since the BSA is already incorporated. If you do choose to use your old tubes of NEBuffer we recommend adding BSA (100ug/ml) to ensure optimal activity of your enzyme.
*BSA will not harm the reaction and can enhance it. After extensive testing, we have found that DTT is not necessary for restriction enzyme activity.
Protoscript® II Reverse Transcriptase (formerly named M-MuLV Reverse Transcriptase (RNase H-)) from NEB is 47% cheaper than SuperScript® II!
Happy New Year to all our Customers!
This year we are celebrating 20 years of supplying UK scientists with the best reagents available.
Back in 1993, when the NEB UK office opened, the majority of your orders reached us by phone or fax and some even came by post. In 2013, the vast majority of you are now able to take advantage of electronic ordering and invoicing. With free shipping on all orders, and next day by noon delivery, we are dedicated to giving you the best service available.
Thank you for choosing NEB for your research needs: we look forward to being your supplier of choice for the next twenty years, and beyond.
 | Both NEB and CST Catalogues are published once every two years, a strategy which contributes to our efforts to minimise our environmental impact. The CST 2013-14 Catalogue and Technical Reference is being mailed during January 2013. The 2013-14 NEB Catalogue and Technical Reference will be available from March - until then please continue to use your 2011-12 NEB Catalogue. |
View our Price Lists page for price list file download options (current prices are not published in the NEB or CST catalogues).
To continue to meet and exceed expectations of customers who manufacture and sell molecular diagnostics, which may be regulated as medical devices, New England Biolabs has voluntarily adopted and been granted ISO 13485:2003 certification for its design, development and distribution of standard and custom molecular biology and related reagents.
"Our decision to become ISO 13485 certified was fuelled by our long established history and passion for providing our customers with the very best products and services in the Life Sciences industry," states Lance Goodreau, Director of Quality Management Systems at NEB.
We are pleased to announce an end to UK mainland delivery charges!
From January 2012 all orders placed with NEB UK are free of delivery, ice and dry ice charges*.
In January 2011 we reduced delivery charges with the introduction of ambient temperature shipping for CST antibodies. This January we are abolishing delivery charges altogether. We hope that this move will simplify ordering and invoicing procedures for all of our customers.
*Excludes Republic of Ireland, N. Ireland and exports
More information on ambient temperature shipping
As a result of the 2010 acquisition of Finnzymes by Thermo Fisher Scientific, there continues to be some confusion as to which life science companies have the rights to manufacture and sell Phusion® High Fidelity DNA Polymerase. To help clarify the situation, New England Biolabs has put together a list of Frequently Asked Questions. We encourage you to forward this information to any of your colleagues who have similar questions.
In summary the situation is as follows:
| New England Biolabs is currently supplying and will continue to supply Phusion® High Fidelity DNA Polymerase, both as a stand-alone enzyme and accompanying buffer, and ina number of master mix formualtions. NEB will also include Phusion® High Fidelity DNA Polymerase in various kits, including the NEBNext® range of products. It is important to note that the Phusion® High Fidelity DNA Polymerase products available from NEB all have new catalogue numbers. This reflects the fact that they are now manufactured by NEB. However, other than this, they are the same products, produced from the same biological starting materials and to the same specifications as the Finnzymes/Thermo Scientific products. As we state on the Phusion web page "Phusion® High Fidelity DNA Polymerase was developed by Finnzymes Oy, now part of Thermo Fisher Scientific. This product is [now] manufactured by New England Biolabs, Inc. under agreement with, and under the performance specifications of Thermo Fisher Scientific." We have also carried out extensive quality testing to ensure that there are no differences between the two sources of enzyme. The list prices for the NEB manufactured products have not changed. The price that you paid in 2010 will remain the same in 2011. |
From January 2011 we are shipping the majority of CST antibodies at room temperature > more information
| NEBNext® is a series of highly pure reagents that facilitate sample preparation of DNA and mRNA for downstream applications such as next generation sequencing, and expression library construction. Available in sets, master mixes and modules, these robust reagents undergo stringent quality controls and functional validation, ensuring maximum yield, convenience and value. We currently supply great value kits validated on Illumina® GAII, Roche/454 GS FLX Titanium™ and SOLiD™ 3. Press Releases for NEBNext® Reagents: |  |
Illumina is a registered trademark of Illumina, Inc.
GS FLX Titanium is a trademark of Roche.
SOLiD is a trademark of Life Technologies.
| As part of our ongoing commitment to the study and improvement of restriction enzymes, we are pleased to announce an expansion to our line of High Fidelity (HF) restriction enzymes. These engineered enzymes have the same specificity as their established counterparts. However, certain properties have been altered, including buffer requirements and enzyme fidelity. These modifications provide customers with more flexibility in setting up their restriction enzyme digests and they are offered at the same low price as the standard enzymes. The following HF enzymes are currently available: |  |
Simple, Versatile and Powerful Tools for Protein Function and Localization Studies
| New England Biolabs introduces a set of tools for the specific labeling of fusion proteins with synthetic probes that help scientists illuminate various aspects of protein function, including a variety of dynamic processes in live cells and in cell lysates. Developed by scientists at the Ecole Polytechnique Federale de Lausanne, these "SNAP-tag technologies" provide simplicity and extraordinary versatility to the imaging of proteins in live and fixed cells and to the study of proteins in vitro. The creation of a single gene construct yields a tagged fusion protein capable of forming a covalent linkage to a variety of functional groups, including fluorophores, biotin, or beads. > more information |  |